G-CSF (Uterine Wall Healing Fertilization)

Uterine wall thickness during IVF treatment is an important clinical sign that determines the chances of the embryo to adhere to the uterine wall. The thin uterine wall is usually determined as 7mm below the uterine wall by transvaginal ultrasonography, which reduces the chance of pregnancy. There are studies suggesting that white blood cell (leukocyte) growth factor (G-CSF granulocyte colony stimulating factor - Filgrastim) treatment is applied as an infusion into the uterus using fertilization catheter in patients who do not thicken the uterine wall despite routine estrogen treatment.

Although there is no gold standard in this regard, that is evidence-based treatment, successful results have been reported with this treatment.

Administration Type:

In the case of fresh embryo transfer, 300 µcq (0.5 ml) granulocyte colony stimulating factor (Filgrastim) is infused into the uterus on the day of hcg (ovo fracture injection). Your treatment will then be resumed without any change in your IVF treatment protocol. 

In Frozen Embryo Transfer trials, when you come to control on 2nd day of your menstruation, the thickness of the uterine wall, cysts in your ovaries are checked and if your doctor deems necessary, after evaluating your serum estrogen value, you will use the drug treatment given to you after evaluating your estrogen value, and then use it in the manner and time that your doctor recommends. Filgrastim infused - granulocyte colony stimulating factor of 300µcq (0.5 ml) with the help of injection catheter. Then, treating your uterus wall for embryo transfer continues in the way your doctor sees appropriate.  

In the presence of adhesions polyps, fibroids or other possible pathologies within the uterus, first of all treatments are applied to eliminate the problems that may prevent the implantation.

In patients with recurrent miscarriages, or in patients with recurrent IVF failure (implantation failure) as appropriate, the systemic (subcutaneous injection) may be administered in addition to intrauterine administration, if your doctor considers it appropriate.